Understanding Alzheimer’s and the Path Forward, with Eric Siemers, MD

When families first receive an Alzheimer’s diagnosis, it’s important to understand that the stage of the disease will guide many decisions. Early detection is critical, especially with new US Food and Drug Administration (FDA)-approved treatments which slow progression but work best during the mildest stages, such as mild cognitive impairment (MCI) or early-stage dementia. Unfortunately, many people are diagnosed later in the disease when symptoms like memory loss and behavioral changes are more noticeable. This delay in diagnosis often means that families are already dealing with significant changes by the time they seek help.

In an interview with The Educated Patient, Eric Siemers, MD, chief medical officer at Acumen Pharmaceuticals, explains that navigating an Alzheimer’s diagnosis involves early intervention, caregiver support and planning for the future.

For those in the later stages, caregivers become essential to the patient’s well-being. However, it is crucial for caregivers to prioritize their own health as well, as caregiving can be physically and emotionally draining.

“It's a little bit like what you hear on the airplane—if the oxygen mask drops, put on yours before you help those around you. You've really got to watch out for the caregiver as much as the patient,” Siemers says.

In contrast, individuals diagnosed in the early stages—those with MCI or mild dementia—still have time to explore more proactive options. One of the most valuable steps they can take, according to Siemers, is to participate in clinical trials. These trials are vital, offering not only access to cutting-edge treatments but also comprehensive medical care. Participants often receive detailed health assessments which help diagnose Alzheimer's and might also detect unrelated health issues that can be treated early. These trials offer patients the chance to contribute to research and benefit from emerging therapies that could improve their quality of life.

Although current treatments can’t stop Alzheimer’s entirely, they do offer hope for slowing the progression of the disease. As a result, families need to plan for the future by considering financial decisions, employment and personal milestones. While there are promising developments in treatment, the progression of Alzheimer’s will continue, making it important for families to think ahead.