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Health Resources Hub / Infectious Disease / Influenza

Understanding Measles in the United States: History, Outbreaks and Prevention

Discover how measles spread before the vaccine, the worst outbreaks in U.S. history and how immunization changed public health.

By

Lana Pine

 |  Published on February 12, 2025

5 min read

Understanding Measles in the United States: History, Outbreaks and Prevention

Credit: Adobe Stock/Feng Yu

Measles is a highly contagious viral disease that has had a significant impact on public health in the United States. Despite advances in vaccination, occasional outbreaks still happen. In this article, we explore the history of measles in the U.S., major outbreaks, the development of the vaccine, and what individuals can do to protect themselves and their communities.

First Reports of Measles in the U.S.

Measles has been present in the U.S. for centuries, with documented cases dating back to the 18th and 19th centuries. The disease was notorious for spreading rapidly, especially in densely populated areas. Before widespread vaccination, measles was a common childhood illness, often leading to serious complications such as pneumonia, encephalitis (brain inflammation) and even death. By the early 20th century, measles was a leading cause of childhood mortality.

Peak Measles Outbreaks

The U.S. experienced several major measles outbreaks before the development of a vaccine. In the early 20th century, nearly every child contracted measles before adolescence. The worst outbreaks occurred in the 1950s and early 1960s, with an average of 3 million to 4 million cases reported annually. In 1958, a particularly severe outbreak led to almost 800,000 reported cases and approximately 552 deaths. These staggering numbers underscored the urgent need for a preventive measure.

Creation of the Measles Vaccine

The breakthrough in measles prevention came in 1963 when Dr. John Enders and his colleagues developed the first effective measles vaccine. This single-dose vaccine significantly reduced transmission rates, which lead to a steady decline in cases. In 1968, an improved version of the vaccine was introduced, further enhancing its effectiveness.

To maximize protection, the measles vaccine was eventually combined with vaccines for mumps and rubella, creating the MMR (measles, mumps, and rubella) vaccine in 1971. The introduction of a second dose in the late 1980s provided even greater immunity, leading to a dramatic decrease in cases. By 2000, the Centers for Disease Control and Prevention (CDC) declared measles eliminated in the U.S., meaning there was no continuous disease transmission for over a year.

Is There a Cure for Measles After Vaccination?

There is no specific cure for measles; treatment primarily involves supportive care. Patients are advised to rest, stay hydrated, and manage symptoms including fever and cough with medications like acetaminophen or ibuprofen. In severe cases, hospitalization may be required, particularly for those with weakened immune systems.

Although the vaccine provides strong protection, individuals who contract measles despite vaccination typically experience a milder illness. The best defense remains vaccination, which provides over 97% efficacy after two doses.

Recent Measles Resurgence and the Importance of Vaccination

Despite the vaccine’s success, the U.S. has seen a resurgence in measles cases due to declining vaccination rates in some communities. In 2019, the country experienced its largest outbreak in over 25 years, with more than 1,200 confirmed cases. The outbreak was largely attributed to misinformation about vaccine safety and lower immunization rates in certain regions.

Public health experts emphasize the importance of maintaining high vaccination coverage to prevent future outbreaks. The CDC recommends that all children receive two doses of the MMR vaccine, with the first dose scheduled at 12 to 15 months and the second at 4 to 6 years old. Adults who have not been vaccinated should also consider immunization, particularly if they plan to travel internationally.

Helpful Resources

For those seeking more information about measles and vaccination, the following resources are highly recommended:

Measles, once a major public health threat in the U.S., has been largely controlled due to effective vaccination programs. However, periodic outbreaks remind us of the importance of maintaining high immunization rates. By staying informed and ensuring vaccinations are up to date, individuals can help prevent the spread of measles and protect public health.