Surviving C. diff: Maryann Webb’s Journey of Recovery and Advocacy

Maryann Webb’s struggle with Clostridioides difficile (C. diff) began after a hospitalization for diverticulitis, during which she received strong antibiotics. Weeks later, she developed severe symptoms, including diarrhea, cramping, nausea and vomiting, leading to multiple hospitalizations. Despite repeated tests, C. diff was initially misdiagnosed due to false negatives, allowing the infection to intensify over months.

Once correctly diagnosed, Maryann—now a member of the Peggy Lillis Foundation (PLF)’s Board of Directors—endured ineffective treatments, including rounds of antibiotics and extreme isolation due to the infection’s contagious nature. Over three years, C. diff consumed her life, leaving her physically and emotionally isolated, and triggering medical post-traumatic stress disorder (PTSD). At her lowest, she began to prepare for the end of her life.

After exhausting conventional treatment options, Maryann was finally approved for a fecal microbiota transplant (FMT) under emergency authorization. Remarkably, she felt significantly better just hours after the procedure, which she credits for saving her life.

With newfound determination, she resolved to support others facing similar struggles, motivated by her own experience.

This year, Maryann will be honored by the PLF at the organization’s 15th Annual Changing the Odds Gala in November, where she will be presented with the Advocate Award.

She emphasizes the importance of resources for patients with C. diff and their families and directs people to the PLF’s website, a nonprofit resource hub that includes peer support groups, survivor stories, treatment information and access to professionals who perform FMTs.

Reflecting on her experience, Maryann emphasizes the profound impact of delayed and inadequate access to effective treatment, as well as the lack of awareness and support for C. diff patients. Today, she advocates for better understanding, treatment options and support networks for those affected by C. diff and continues to encourage others to help bring hope and awareness to those affected by this devastating infection.